This is usually the case, but their are some exceptions.
Take Advice Dog:
The reason that he's still somewhat popular is because he's evolved with many different spinoff memes that take the basic premise and twist it ever so slightly to make something new. The best example would be Pokeparents:
This meme is almost endless, what with all the pokeman. Just connect one pokemon to one type of person (cool dad, lazy dad, business mom, ect) and you have something funny. With all the different pokemon out there, it's also a safe bet that you'll still find something funny from time to time.
The only real way to keep a meme around is not to spam or overuse it. That's a good way to kill something, like what radio does to music on a regular basis.
God, I know way too much about this....
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