Anime about loneliness and communication

[LightSpectra]

I love Evangelion because of its primary theme of the inability to emotionally connect to other human beings. Is there any other anime/manga out there that deals with this philosophical-psychological question in a sophisticated way?

[Arumachinogunjou]

Hmm... I'll start watching that now.

[Ωmega]

Try Serial Experiments Lain and Boogiepop Phantom

[November]

I agree with Serial Experiments Lain.
I also recommend Ergo Proxy.

[Masakisu]

texhnolyze texhnolyze texhnolyze texhnolyze texhnolyze

[Ichigo!]

I don't know if this counts but there's Chaos Head.

[Ωmega]

texhnolyze texhnolyze texhnolyze texhnolyze texhnolyze
lol, yes, those who like Lain tend to enjoy Texhnolyze too, especially since both are done by Yoshitoshi Abe and Chiaki Konaka

[Screwby]

I've never seen Evangelion and I don't really get what you mean in a sophisticated way so my recommendation might be far off.
One anime that talks about loneliness is NHK ni Youkoso.

[Ezza Obsuna]

Now and then, here and there fits here. I actually like it.