Yes! Right in the racing capital of the world is where you will find Anime Crossroads. From September 24-26th 2010, you can experience a large anime convention with tons to do. Located at the Indianapolis Marriott East. http://www.animecrossroads.com/index.html
I plan on going, and I may even hold a panel there. I'm trying to bring a classmate and co-worker who doesn't know anything about anime, he wants to go to see what it is like, and I'm doing what I can to get him to go. Are you planning on going, or know of anyone wanting to go?