So far as I know, RE5 is the only one for the XBox360. I would highly recommend it even if you haven't played any of the other REs, because they explain the backstory and history *such as it is* while you're playing along.
If you can find some of the other REs - all except Outbreak, 0, Gun Survivor and Gaiden - play them if you have a PS2 or a Wii. (The ones I mentioned... gah, I either despise them or haven't played them.)
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