There seems to be some confusion amongst some people who think its a follow up to the anime that was on tv and then the film.
but its been said that this new Full Metal Alchemist which will be starting April 2009 will infact be a complete reboot by the same Animators as the original series but this will simply be more concentrated on the manga.
basically same characters.. different story, i heard that the enemy in the manga is called "Father" and not Dante such as the anime said. and im sure that its not Father as in their own dad.
if you havent seen it, heres a tv advert for the new series:
So ye, by the advert it seems like it IS a complete new series based on the manga, and you can find out more in the latest issue of the Manga ( 90 ) which is still running and although i only had a small glimpse of it since i dont want to ruin it for myself, it is quite different.
hope this was of use to anyone.
Cant wait till 09!