Now I know it all depends. If you are reading the manga, Ed is actually a boy.
However in the Anime, Ed is a girl.
In your own personal opinion, what do you think Ed was truly meant to be?
Mr. Edward Wong Hau Pepelu Tivrusky IV?
Ms. Edward Wong?
Personally, I feel she was originally intended to be a girl. She states so herself in the Movie. So why would they twist it up in the Manga, hmm?