Right, first off I will warn readers again, this thread does contain major spoilers. if you have not seen all of wolf's rain then do not read on it will spoil the ending for you!!!!!
Ok I hope this makes some sort of sense - its later here.
as a point my internet is bust up something horrid so I can't google to find spelling names - so there will be errors which I will edit once I can.
At the end of wolf's rain you see the four main characters in a city environment similar to modern day life. In this city you see them as people walking around - in the case of Tsume you see him riding a motorcyle and from that you can deduce that they have turned into men. You also do not see Cheza, yet you do see a lunar flower, which Kiba seems to charge towards and from this and the comment that Cheza makes about being in the wrong form when her body attempts to grow it might be assumed that she is the flower.
I however would like to contst this line of thinking based upon the introduction to the show. In this you clearly see the same city background of the modern day times shown at the end of the series. In this backdrop you not only see Kiba as a wolf but also see a sad looking Cheza in human form (in the rain). This started me thinking that things also went wrong the second time around as well (for a cause there's the eye) and that Cheza somehow also ends up as a human-like form again. As for whether the wolves are human or wolf, only Tsume is shown in a situation which a wolf could not fake, unless - and here things get a little extended - having been around and mingling with people and affecting thier minds to show what they want people to see as opposed to what they really see, would it not be possible that Tsume is using the illusion of being on a bike to blend in (you can run faster on roads than you can as a person on the pavment without attrackting attention). Remember that Tsume is the only wolf who throught the series uses a prop - his knife - to represent his fangs - so it could be possible for him to extend the illusion further.
well I hope that makes some sense and that there are other wolf fans about to extend this