Quite a few names hit my list as top contenders. But what is a villain? Is it simply the one who does not agree on the heroes views and opinions? Is the Villain someone you yourself do not like? Good and Evil is a difference of opinion such as I'm on the side of Vampires VS Warewolves, I root for guys like Edge (Bad Guy/Heel), AJ Styles (Bad Guy/Heel), and John Cena (Baby Face/Good Guy) but I boo guys like Bautista (Face), Jeff Jarrett (Face), and Triple H (Face).
I'm going to have to say that for this debate the Villain is the guy you're fighting against for atleast half the game. Now there are such great Villains such as Iggy, 4 Ghosts, and my favorite Giovanni. Not bosses or sub-bosses or guys who aren't at the end or are so little someone else is the main vaillain and not the final boss.
1.) Eve - Parasite Eve - She set people a flame with her voice, melted people into goo from their skin to muscles and organs. She was tough. She had some great music. She had great moves. She had some good points on why she's doing what she did. The only reason you don't melt or burst a flame is because you two have the same DNA running in you. Thing is: YOU'RE NOT SISTERS. I won't say how, it'll hurt some of the story. Hats off to one the best Villains.
2.) Dracula - Castlevania Series - From 1096 to 2036, the King of Vampires, Count Vladir Trepes or "Dracula" as he's simply known as. Only those with Belmont DNA can brandish the Vampire Killer and slay the Prince of Darkness. From Leon Belmont and Sonia Belmont to Soma Cruz. Not only has he lost to people with dilutted Belmont Blood but lost to his own son and his HUMAN Reincarnation. Dracula returns either very 50 years or by a dark ritual, he returns with minions giving our heroes a fight. Castlevania games have never left a person bored, and Count Dracula alays returns with a new form that's "His Stronggest YET". Kudo to Count Dracula for giving me and other plays lots of fight and fun.
3.) Grahf - Xenogears - This dude is evil. Grahf is chasing Fei because of a hidden power and personality: ID. Grahf feels that because God allowed his beloved childhood friend Elly to die. He feels that he should become the Slayer OF God. For 500 years he searched for the one who can complete his power. He one day fiends Fei in a village and has the village destroyed to awake the true power Fei has lieing dormant in his body. Grahf had found Fei before that day and caused Fei to murder his mother unwillingly. Through his anger and hatred of God, he become immortal and craves power enough to slay God himself.
4.) Krelian - Xenogears - Krelian on the other hand was head of a Rebellion against an empire called Solaries who took people that dwelled on land and made them slaves. In land Nisan, Elly or Sophia headed a relgious Sanct. He discovered Nanotechnology which later becomes his weapon of Retribution and Undueing. When Sophia sacraficed her life to save her friends and followers life, unlike Grahf who wanted to destroy God. Krelian felt "If God does not exist... I shall create God with my own hands." As time passed he become sinister and currupt my turning people in to creatures known as wells, half-decayed living beings. In turn he also has them butchered to become food. He spends his time tryign to find the contact for God, he works throughtout time with a woman named Miang to help him in quest to create God with his own hands. He and several others find "Deus" (if you know Greek, Deus = God) and his resting place.
Those are the best villains as far as I'm concerned. Noone else got my goat as good as the above. Rather it be story line wise or game play wise. Eve and some forms of Dracula are freaking HARD.