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Thread: Naked mole-rat gives cancer clues

  1. #1
    Member iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime has a reputation beyond repute iAnime's Avatar
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    Default Naked mole-rat gives cancer clues

    Naked mole-rat gives cancer clues

    By Helen BriggsBBC NewsA rodent that never gets cancer could hold the key to preventing or treating malignant tumours, say scientists.
    Lab studies show the skin cells of the naked mole-rat are high in a natural sugary substance that stops tumours developing.
    The findings could lead to new human cancer therapies in the long term, researchers report in Nature journal.
    A similar version of the chemical is used as a medicine to treat arthritis and in anti-wrinkle jabs.
    A team led by researchers from the University of Rochester, New York, US, investigated the anti-cancer properties of the naked mole-rat.
    Unlike other small rodents, such as rats and mice, the curious creature does not get cancer in later life.
    Tissue repairThe US team, led by Andrei Seluanov and Vera Gorbunova, cultured skin cells from the rodent in the laboratory.
    They found that the animal's tissues were rich in high molecular weight hyaluronan (HMW-HA), a gooey sugar that is involved in tissue repair.
    Similar versions of the substance are licensed to relieve pain in arthritis and are used as cosmetic fillers to treat wrinkles, say the researchers.
    Experiments show that when HMW-HA is removed from naked mole-rat cells, they become susceptible to cancer, suggesting it plays a role in making the rodent "cancer-proof".
    Dr Gorbunova told BBC News: "Studying animals that are naturally cancer-resistant can be very rewarding and can lead to discovery of mechanisms that can benefit humans in terms of treatment and prevention of cancer."
    Flexible skinThe researchers think the substance gives the naked mole-rat its distinctive, elastic "baggy" skin, which it needs to squeeze through underground tunnels.
    While it has probably evolved to provide the rodent with an exceptionally flexible skin, it also gives protection against cancer, possibly by stopping cancerous cells from dividing.
    The next step, they say, is to test the chemical in mice, then human cells.
    Dr Seluanov added: "There's indirect evidence that HMW-HA would work in people.
    "It's used in anti-wrinkle injections and to relieve pain from arthritis in knee joints, without any adverse effects.
    "Our hope is that it can also induce an anti-cancer response."
    The study, carried out with scientists in China and Israel, is published in the journal Nature.
    No beautyCommenting on the research, Oliver Childs of Cancer Research UK said new cancer treatments from the research were "a long way off".
    "They're not going to win any beauty contests, but these curious creatures have long interested scientists because of their exceptionally lengthy life spans and resistance to cancer," he said.
    "This fascinating research builds on previous work revealing the biological tricks mole-rats have evolved to prevent cancer.
    "It's a long way off, but it will be interesting to see if further research can find a way to use hyaluronan to help prevent or treat cancer in humans."
    http://www.bbc.co.uk/news/health-22961694

    Lol the naked mole picture and title made me read this article in the first place (`・ω・´)”. Its cool that the mole has another anti cancer mechanism "HMW-HA" substance that helps the organism become cancer resistant. But if the mole does have a mutation to the gene that makes "HMW-HA" then they would also be more prone to cancer.

  2. #2
    Senior Member Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa has a reputation beyond repute Kumagawa's Avatar
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    Default Re: Naked mole-rat gives cancer clues

    from now on I'll eat those animals and become invincible

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    Default Re: Naked mole-rat gives cancer clues

    Jealous about the Naked Mole Rat being cancer resistant and humans still aren't?
    Good ol' Dogs never Die, they just keepin on livin' till their time comes.


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  5. #4
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    Default Re: Naked mole-rat gives cancer clues

    Quote Originally Posted by DeathBlade/13.666 View Post
    Jealous about the Naked Mole Rat being cancer resistant and humans still aren't?
    Lol naked moles are quite overpowered now aren't they ( ̄ー ̄). Picture above describes it XD!

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    Default Re: Naked mole-rat gives cancer clues

    Quote Originally Posted by iAnime View Post
    Lol naked moles are quite overpowered now aren't they ( ̄ー ̄). Picture above describes it XD!
    lol It literally makes Rufus the most epic character from Kim Possible too.
    Good ol' Dogs never Die, they just keepin on livin' till their time comes.


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    Default Re: Naked mole-rat gives cancer clues

    Time to buy myself a naked mole rat suit! Damn mole rats!
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    Default Re: Naked mole-rat gives cancer clues

    Rufus was always the most badass character in Kim Possible anyways...

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    Default Re: Naked mole-rat gives cancer clues

    All hail our new supreme overlords.


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    Default Re: Naked mole-rat gives cancer clues

    lolwut?

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