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Japanese with english subs! The voice acting is way better and itīs more authentic somehow...
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Depends. There are certain series where I definitively prefer the English voice actors (The Melancholy of Haruhi Suzumiya, Cowboy Bebop), several others where Japanese with subtitles is preferred (Hell Girl, Elfen Lied, Serial Experiments Lain), and others still where I don't particularly care (Berserk, School Rumble, Rozen Maiden).
Overall, however, I tend to go for Japanese with English subtitles wherever possible.